Dev121723 1390..1395
نویسندگان
چکیده
Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismaldevelopment. Inparticular, LPAsignallinghasbeenshown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying poster, we review the developmentally related features of LPA signalling.
منابع مشابه
Force Field Modeling of Conformational Energies: Importance of Multipole Moments and Intramolecular Polarization
The ability of force fields to reproduce relative conformational energies for seven molecules is probed. The correlation against LMP2/cc-pVTZ results for standard force field employing fixed partial charges deteriorates as the molecules become more polar. Inclusion of multipole moments and intramolecular polarization can improve the correlation, and both contributions are of similar importance....
متن کاملLack of improvement in outpatient management of congestive heart failure in the United States.
controversy? Curr Oncol. 2009;16(3):1-2. 6. Thompson IM, Goodman PJ, Tangen CM, et al. The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349(3):215224. 7. Sakr WA, Grignon DJ, Crissman JD, et al. High grade prostatic intraepithelial neoplasia (HGPIN) and prostatic adenocarcinoma between the ages of 20-69: an autopsy study of 249 cases. In Vivo. 1994;8(3):439...
متن کاملA network-based data mining approach to portfolio selection via weighted clique relaxations
متن کامل
Reward Processing by the Opioid System in the Brain
A. The endogenous opioid system and natural reinforcement 1383 B. The endogenous opioid system and drugs of abuse 1387 C. Perspectives: extending studies to animal models of drug addiction 1393 IV. Genetic Manipulation of the Opioid System, Reinforcement, and Drug Dependence 1393 A. Opioid receptor knockout mice 1393 B. Opioid peptide knockout mice 1394 C. Conclusion 1395 D. Perspectives: towar...
متن کاملOn the least signless Laplacian eigenvalue of a non-bipartite connected graph with fixed maximum degree
In this paper, we determine the unique graph whose least signless Laplacian eigenvalue attains the minimum among all non-bipartite unicyclic graphs of order n with maximum degree Δ and among all non-bipartite connected graphs of order n with maximum degree Δ, respectively.
متن کامل